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Pilomatricoma differential diagnosis

Pilomatricoma differential diagnosis Pilomatricoma is a rare, benign neoplasm that occurs from hair cortex cells. It used to be called malherbe's pilomatrixoma, or qualified epithelioma. the reported insidiousness of 500-2000 they are 0.12% of cutaneous neoplasms and 20% of all hair follicle-related tumors make up more often in women; F:M ratio = 3:2 is more common i Han K, Ha HJ, Kong JS, Myung JK, Park S, Kim JS, et al. Importance of Individual Ghost Cells in Fine-Needle Aspiration Cytology Diagnosis of Pilomatricoma. J Pathol Transl Med. 2018 Jan. 52 (1):45-50 Differential diagnosis of pilomatricoma. Matricoma: First described by Ackermann, it is a tumour of the same cellular constituents, but varies by its silhouette. It is largely a nodular or multinodular predominantly basaloid tumour, which lacks the typical central cystic component, and is described as having small areas of shadow cell formation. Differential diagnoses were provided in 56 (62.2%) radiology reports. Pilomatricoma was mentioned in 12 (13.3%) reports as a diagnostic possibility. In 11 (12.2%) reports pilomatricoma was the first and in seven (7.8%) the only diagnostic consideration

pilomatricoma - Humpath

The scan of pilomatricoma is described as a doughnut within the dermis (mid layer of the skin) with a tail (the tail denotes calcification). Alternatively, the calcification may be detected by X-ray. A biopsy will help to establish the cause of the lesion. Alternatively the whole lesion can be removed, providing both diagnosis and treatment 2.5 Differential diagnosis; 2.6 Histopathology; 2.7 General treatment; 2.8 Medical therapy; 2.9 Surgery; 2.10 Surgical follow up; 2.11 Prognosis; 3 References; Disease Entity. A pilomatrixoma is a benign, firm subcutaneous mass found under the skin. It most commonly presents as a single lump found on the face, scalp, eyelids, eyebrows, neck, or.

  1. 274901004 - Pilomatricoma Look For. Subscription Required. Diagnostic Pearls. Subscription Required. Differential Diagnosis & Pitfalls. Epidermoid cyst can frequently be identified by observing an overlying punctum. Pilar cyst is usually deeper than a pilomatricoma. A pilomatricoma is typically firmer and less regular in shape than a dermoid.
  2. Definition / general. Also called pilomatricoma, calcified epithelioma of Malherbe. Benign tumor arising from hair matrix. Usually children and young adults in head, neck or upper extremities. Proliferating portion of tumor composed of small round blue cells - a pitfall on fine needle aspiration. Aggressive pilomatrixoma
  3. A pilomatricoma is an uncommon, benign neoplasm thought to arise from hair cortex cells. It was formerly referred to as pilomatrixoma or calcifying epithelioma of Malherbe. Epidemiology the reported incidence ranges between 1 in 500-2000 they.
  4. Pilomatrixoma Differential Diagnosis. The differential diagnosis for Pilomatrixoma involves differentiating the disease from other similar conditions like Dermoid Cyst, Chondroma, Degenerating Fibroxanthoma, Giant Cell Tumor, Ossifying Hematoma and Sebaceous Cyst. Pilomatrixoma Treatmen
  5. The differential diagnosis includes epidermal inclusion cyst and other adnexal tumors. A pilomatricoma can discharge a chalky material and will continue to grow slowly if left untreated; it may also become inflamed and tender. Therefore, surgical excision is the treatment of choice
  6. This report presents a case of a pilomatricoma of the left chest that was initially ignored due to the limited extent of access to medical care in Palau, and subsequent treatment for cervical cancer. The paper helps to emphasize the importance of a vast differential diagnosis, especially in those patients from the Pacific Islands
  7. Pilomatricoma is a benign skin tumor derived from the hair matrix. We present a case of 40 years female who presented to the outpatient department with history of swelling in the left ear lobule for the last 2 years. Pre-operative diagnosis o

What are the differential diagnoses for Pilomatrixoma

Background and objectives. Pilomatricoma is the second most common skin tumor in childhood and youth and it has a broad differential diagnosis. The main objective of the present study was to determine the incidence of pilomatricomas in our hospital and to analyze the following variables: patient age and sex, tumor site, symptoms, previous trauma, clinical diagnosis, associated diseases, number. Proliferating pilomatricoma represents a distinctive histopathological entity that should be differentiated from other benign and malignant neoplasms with hair matrical differentiation. The differential diagnosis includes classical pilomatricoma, pilomatrical carcinoma, and basal cell carcinoma with matrical differentiation The standard treatment of pilomatricoma is wide local surgical excision. Recurrences are reported to be less than 3%.10 Our experience with this case highlights the uncommon age and site of presentation. As it can occur at unusual sites where it is frequently misdiagnosed, it should be included as a differential diagnosis in al

Pilomatricoma pathology DermNet N

Pilomatricoma (Also Pilomatrixoma) Definition. Pilomatricoma, also known as trichomatricoma and previously referred to as calcifying epithelioma of Malherbe, is a benign tumour of hair matrix cells. It is considered to be a hamartoma. Pilomatricomas account for 10% of all types of skin nodules and/or cysts in childhood [1]. Pathogenesis Because preoperative diagnosis of pilomatricoma is usually incorrect, careful clinical examination and a high index of suspicion would result in a more accurate diagnosis. Complete surgical excision is the treatment of choice. Otolaryngologists should consider pilomatricoma in the differential diagn Pilomatrixoma, previously thought to be a rare lesion, is one of the most common causes of superficial head and neck masses in children. This study demonstrates clinical presentations that should help guide differential diagnoses. We demonstrate associations that are consistent with the proposed pat Here, we describe a case of pilomatricoma of the periorbital region in a young Indian female patient. We believe that its inclusion is essential in the differential diagnosis of hard masses of the maxillofacial and paraoral regions. PMID: 18797106 [PubMed - indexed for MEDLINE] Publication Types: Case Reports; MeSH Terms. Adolescent; Diagnosis. These ultrasound features are overall suggestive of a benign pathology and possible differential diagnosis includes sebaceous cyst, dermoid cyst, or epidermal inclusion cyst. Case Discussion This lesion was completely excised and diagnosed as pilomatricoma or calcifying epithelioma of Malherbe on histopathology

Pilomatrixoma, which is also known as pilomatricoma and the calcified epithelioma of Malherbe, is a variation of the epidermal cyst and should be included in the differential diagnosis DIAGNOSIS. Benign pilomatricoma of the breast. DISCUSSION. Pilomatricoma (PM) is a rare but most-often benign skin appendage tumor of hair matrix origin. Malherbe and Chenatais first described the tumor in 1880 as a calcified epithelioma of Malherbe from sebaceous glands, but in 1961, Forbis and Helwig proved that the tumor originates.

No differential diagnosis was given in 34 (37.8%) imaging reports. In the radiology reports, pilomatricoma was suggested as a possibility for 12 (13.3%) lesions. Foreign body reaction (13.3%), dermoid cyst (10.0%), and sebaceous cyst (8.9%) were other leading suggested diagnoses. In six (6.7%) reports, lesions were described as aggressive tumors In this study, we discuss the epidemiology of the tumor, clinical and histopathological findings, differential diagnosis and treatment outcome of pilomatrixoma in the light of our experiences with 20 cases. [go.gale.com] Epidemiology Pilomatricoma accounts to 20 % of all hair follicle related tumors in most series. Therefore, it can be. The differential diagnosis of pilomatrixoma is varied. Pilomatrixoma should be differentiated from epidermal and dermoid cysts. Epidermal cysts are firm, round, and mobile, and they have normal overlying skin The patient was successfully treated with surgical excision. This case presented a unique diagnostic challenge, as the lesions exhibited features of several common diagnoses. In general, surgical management of pilomatricoma is curative, and recurrence is rare Conclusion: Pilomatrixoma are an important differential diagnosis of unclear masses in the head and neck especially in children. The sonographical characteristics are variable and unspecific. A fine-needle aspiration biopsy is not recommended, since false malignant cytologic findings occur quite often

In children, the clinical differential diagnosis is usually more limited. Pilomatricomas can mimic other follicular growths, epidermoid or pilar cysts, dermoid cysts, and brachial cleft anomalies. Lymphadenopathy and foreign body reactions should also be considered The exact cause of pilomatricoma is unknown, but it may be related to a gene mutation in the hair cells. The condition typically appears in very young children, but may also develop in adults. Differential Diagnosis (Other conditions with similar appearance) Epidermal inclusion Cyst Pilar Cyst Lipoma. Diagnosis Key Point Differential diagnosis included hemangioma, branchial cleft cyst, dermoid cyst, epidermoid cyst, vascular malformation, and pilomatricoma. The patient was taken to the operating room for successful left neck mass excision. The apparent punctum was explored intraoperatively, and there was no evidence of subcutaneous tract, sinus, or fistula

Pilomatricoma of Childhood: A Common Pathologic Diagnosis

  1. trasonographic findings of pilomatricoma facilitate accu-rate diagnosis, and if a calcified soft tissue mass is seen at ultrasonography, pilomatricoma should be included in the differential diagnosis. Case Report An otherwise healthy 22-year-old man presented with a two-month history of an expanding mass in the left in-terscapular area
  2. the previous literature. Pilomatricoma should be included in the differential diagnosis of superficial pediatric head and neck masses by any physician involved with pediatric tumors. Key words: pilomatricoma, child, skin neoplasms. Pilomatricoma is a benign tumor originating from hair follicle matrix cells. Althoug
  3. The diagnosis of hemangioma was ruled out by MRI and therefore an open incisional biopsy of the lesion could be safely performed for diagnosis (under a further general anesthetic). On pathological assessment, the tissue was found to consist of fragments of a benign pilomatricoma showing the typical elements of basaloid foci, giant-cell reaction.
  4. Pilomatricoma (PMC) is a relatively uncommon benign skin neoplasm arising from the skin adnexa. Since the first description of PMC in 1880, there has been a gradual increase in understanding of the morphologic features and clinical presentation of this tumor. However, difficulties still persist in making clinical and cytologic diagnosis
  5. Pilomatricoma was first defined by Malherbe and Chenantais in 1880. It is a rare benign soft tissue tumour which is originated In the differential diagnosis, dermoid cyst, parotid tumours in preauricular area, sebaceous cyst, calcified hematoma, brachial cleft, and giant cell tumours should be considered in the head an
  6. Differential diagnosis. The differential diagnosis includes multiple pilomatricomas, mytonic dystrophy, Gardner syndrome, Steinert disease, Turner syndrome.3 Pathologies such as trichoblastic carcinoma, basal cell carcinoma, dermoid cyst, sebaceous cyst, eyelid cyst, eyelid tumour, retention cyst, atheroma, abscess, cavernous vascular tumours, and benign hair follicle tumours such as.

Pilomatricoma DermNet N

diagnosis. Occasionally the epidermis overlying the mass displays a blue or red discoloration and ulceration of the skin is rarely noted. Typically the diameter of the lesion ranges from 1 to 3cm, however larger masses have been reported[3]. The clinical differential diagnosis for pilomatricoma in children includes epidermal inclusio Lymphangiectasia can mimic different types of warts (eg, plantar, genital). [ 29, 30, 31, 12] Cutis marmorata telangiectatica congenita has been described with pulmonary lymphangiectasia. [ 32] Benign mesothelial nodule reflux has been described in acquired cutaneous lymphangiectasia associated with an ovarian clear cell carcinoma. [ 33 Proliferating trichilemmal tumor, also referred to as a pilar tumor or proliferating pilar cyst, and pilomatricoma should also be considered in the differential diagnosis. Proliferating trichilemmal tumor, which varies significantly in biological behavior, is the terminal stage of trichilemmal cyst growth [ 10 , 11 ], the histology of which. The present case suggests that this benign tumor needs to be included in the differential diagnosis in patients who present with an atypical auricular lesion. 1. Introduction. Pilomatricoma is a benign tumor arising from hair follicle matrix cells. It is a relatively common entity, accounting for about 1% of all benign skin lesions

Benign lesions that are symptomatic or cosmetically bothersome can often be managed with simple procedures, such as cryotherapy, electrosurgery, or excision. The clinical features, diagnosis, and treatment of some common acquired skin lesions will be discussed here. Malignant neoplasms of the skin are discussed separately Varied preoperative clinical diagnoses are considered in a case of pilomatricoma but a surprising finding is that the pilomatricoma has almost never been suspected. [1] , [2] The preoperative, differential diagnoses considered by clinicians include dermoid and sebaceous cysts, chondroma, metastatic calcification, osteoma cutis, foreign body. 54 New Journal of Medicine 2015;32:54-56 54 Case report Can P53 and Ki-67 Be Useful in Differential Diagnosis of Proliferating Pilomatricoma? (Proliferatif pilomatriksoman n ayr c tan s nda p53 ve. pilomatricoma are challenging given their overlapping features. There are some clues to differentiate pilomatrix carcinoma from benign pilomatricoma: asymmetry, poor circumscription, atypical basaloid cells, extensive areas of necrosis, infiltrative growth pattern and presence of ulceration. Differential Diagnosis: • Pilomatricoma Finally, pilomatricoma can be associated with other diseases such as myotonic dystrophy (Steinert disease), frontoparietal baldness, sarcoidosis, Turner syndrome, Raynaud phenomenon or Gardner syndrome (23-27). The differential diagnosis for pilomatricoma is varied

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Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Pilomatrixom Pilomatricoma commonly occurs in children and most frequently appears in the head and neck region . Although pilomatricoma is the most commonly excised superficial mass in children after epidermoid cyst and lymph nodes, it is frequently misdiagnosed and not usually considered in the clinical differential diagnosis [5, 6] Although pilomatricoma is a lesion commonly encountered in the maxillofacial region, dental professionals commonly leave it out of differential diagnosis. Professionals should be aware of calcifications like this and for early diagnosis, they should carry out optimal clinical examination by means of radiographs and histopathology The clinical differential diagnosis of onycho-matricoma is extensive, 7,8 but onychomatricoma has characteristic clinical and histopathologic features that allow its separation from other nail disorders and subungual tumors (Table). 9 There are 4 cardinal clinical signs that suggest a diagnosis of onychomatricoma: (1) banded or diffuse. Proliferating pilomatricoma can occur at younger ages and should be considered in the differential diagnosis of solitary lesions in adults and children, even if the lesion is rapidly growing. Start reading the preview of my book A Doctor's Journey for free on Amazon. Available on Kindle for $2.99

Differential diagnoses to consider with pilomatricomas include sebaceous cyst, dermoid cyst, branchial cyst, preauricular cyst, ossifying hematoma, chondroma, lymphadenopathy, foreign body reaction, fibroxanthoma, giant cell tumor, and osteoma cutis. Attempts have been made to diagnose pilomatricoma using imaging techniques Differential Diagnosis : History: Pilomatricoma is the commonest hair follicle-related tumor. It may occur at any age. The majority of patients are under 20 years of age, and females are affected more often than males. The lesion is usually a solitary, deep, dermal or subcutaneous tumor 3-30 mm in diameter situated in the head, neck or upper. Pilomatricoma of childhood: A common pathologic diagnosis yet a rare radiologic one Julie C. Bulman, Seckin O. Ulualp , Veena Rajaram , Korgün Koral Otolaryngology - Head And Neck Surger The present case highlights the importance of considering pilomatrixoma in the clinical and pathologic differential diagnosis of dermal or subcutaneous nodule even in locations other than head and neck region. This is true especially for cytopathologists since they play an important role in the initial diagnosis of these lesions

Because pilomatricoma is hard to diagnose by its form, they can be misdiagnosed and as a consequence mistreated. The differential diagnosis of these lesions should include sebaceous, dermoid and epidermoid cysts, metaplastic bone formation, foreign body reaction, hematoma, osteochondroma, trichoepithelioma, and basal cell epithelioma The diagnosis of pilomatricoma is usually suspected clinically and confirmed by histopathological examination. Preoperative imaging is rarely indicated unless its presentation poses a diagnostic dilemma, such as in our case when misdiagnosis of a primary malignant parotid tumor was made followed by multiple inconclusive FNACs

Pilomatricom

Initially a differential diagnosis of hemangioma or pilomatricoma was clinically made. It was considered likely to be a hemangioma in view of the color even though it was noted to be surprisingly firm. The diagnosis of a sarcoma was considered because of the rapid growth of the lesion The diagnosis of Pilomatricoma was not kept pre operatively as it is an uncommon identity with a reported incidence of 1 in 500- 2000. Pilomatricoma: Another Differential In The Diagnosis Of The Soft Tissue Swellings Of The Ear Lobule, International Journal of Bioassays, 2015, 4 (06), 3983- Diagnosis is through microscopic examination of samples of the tumor cells from fine needle aspiration or biopsy. Canine histiocytomas are normally considered benign tumors; most resolve spontaneously and without treatment within 2 to 3 months. Surgical removal is optional and normally performed only if the tumors cause severe problems for the dog

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Pathology Outlines - Pilomatrixom

A pilomatricoma is an uncommon, benign neoplasm thought to arise from hair cortex cells. It was formerly referred to as pilomatrixoma or calcifying epithelioma of Malherbe.. Epidemiology. the reported incidence ranges between 1 in 500-2000; they make up 0.12% of cutaneous neoplasms and 20% of all hair follicle related tumor Key Differential Diagnosis Issues. • Align transducer obliquely to obtain views not obscured by calcification. • Differential diagnoses. Clinical history, e.g., trauma more in favor of fat necrosis, panniculitis, or myositis ossificans (MO) Radiographs ± CT findings are helpful for analyzing type of calcification

Benign, solitary smooth muscle neoplasm most commonly occurs in subcutaneous soft tissues of lower limb. Usually round or ovoid in shape with long axis parallel to extremity axis. Smooth-bordered, homogeneous, hypoechoic mass without perceivable capsule. Occurs in close proximity to artery or vein. Often hypervascular ± vascular convergence Pilomatricoma is a benign neoplasm composed of basaloid and shadow cells that characterize differentiation toward the hair matrix. reported to occur as a pure mucinous carcinoma. 146,147 It can arise in association with EMPD. 148 The histopathologic differential diagnosis includes metastatic carcinoma to the vulva from various sites. Differential Diagnosis & Pitfalls The primary differential of red-to-yellow papules on a young child is JXG, Spitz nevus, and mastocytoma. Mastocytomas - Similar in color to JXGs, but they urticate when rubbed. Spitz nevi - Pigmented and do not regress over time. Xanthomas (eg, xanthoma disseminatum) Langerhans cell histiocytosis. Pilomatricoma is usually not considered in differential diagnosis of firm skin nodule on eyelid and orbit. This is a report of an unusually, single, firm, nodular, non-ulcerated, painless orbital pilomatricoma located under right lower eyelid of an adult man. This entity has to be considered in the differential diagnosis of such lesion

Pilomatricoma Radiology Reference Article Radiopaedia

The differential diagnosis of pilomatricoma is broad cytologically and depends on the proportion of diagnostic components present. In cases where aspirates contain mainly sheets of anucleated and nucleated squamous cells, a pilomatricoma can be confused with an epidermal cyst or trichilemmal cyst. An important differentiating feature i Pilomatricoma is a common benign cutaneous tumor arising most commonly in the first 2 decades of life. Despite its frequency, pilomatricoma remains a diagnostic challenge to nondermatologists and is misdiagnosed in 45% to 75% of cases.1,2 A concerning clinical and cytologic appearance after fine-needle aspiration (FNA) has contributed to the misdiagnosis of malignancy in several cases.3-5. Differential Diagnosis. Pilomatricoma (pilomatrixoma) is a benign adnexal tumor that recapitulates the hair matrix and demonstrates variable mixtures of basaloid and shadow cells, but is usually histologically distinct from basal cell carcinoma. Pilomatrical carcinoma (pilomatrix carcinoma) is the malignant counterpart of pilomatricoma and.

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Pilomatrixoma - Definition, Causes, Pictures and Treatmen

The diagnosis of pilomatricoma can be made clinically if the characteristics of the tumour are known; pilomatricoma lesions slide freely over the underlying tissue. Graham and Merwin (14) described the 'tent sign', elicited by stretching the skin over the pilomatricoma tumour to feel the irregular surface of mass frequency, pilomatricoma is clinically underdiagnosed and although the differential diagnosis includes numerous benign skin plete lesions (epidermoid and dermoid cysts, swollen lymph nodes, foreign body granuloma, molluscum contagiosum, xanthogranuloma, and adnexal subcutaneous tumors) and malignant lesions (basal cell carcinoma and melanoma).7. Pilomatricoma • Rock-hard, calcified nodule with bluish hue, non-painful • Face (mc), head and neck • F>M • Derived from the hair matrix • Multiple lesions have been associated with myotonic dystrophy (Steinert disease), Gardner syndrome, Rubinstein-Taybi syndrome, and trisomy 9 Cerroni et al . reviewed 118 cases of pilomatricoma and only two of them showed a differential diagnosis with haemangioma. Julian and Bowers revised 209 cases of pilomatricoma, and suggested that 5% of them required differential diagnosis with haemangioma. These last authors named these tumours lymphangiectatic variant of pilomatricoma

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Pilomatricoma - an overview ScienceDirect Topic

Would you consider pilomatricoma as a differential diagnosis? By Yuka Inamura, Hiroo Hata, Keisuke Imafuku, Shinya Kitamura and Hiroshi Shimizu. Cite . BibTex; Full citation; Topics: pilomatricoma, Dermatology,. Pilomatricoma: Second-fifth decades, slow growing mass on flexor surface, mild tender. Color Doppler can provide important information about the vascularity to aid in the diagnosis as well. In cross-sectional imaging, magnetic resonance imaging (MRI) is frequently performed to characterize the soft tissue hand tumor. The differential is.

Pilomatricoma: An Unusual Dermatologic Neoplas

A tumour composed of cells resembling those of the hair matrix, which undergo 'mummification' and may calcify. It may occur at any age from infancy, the majority of the patients being under 20. Females are affected more often than males. The lesion presents as a solitary, deep dermal or subcutaneous tumour 3-30 mm in diameter, situated on the face, neck, or upper extremities. The overlying. The differential diagnosis for pilomatricoma may include nodular subepidermal fibroma, epider-moid cyst, sebaceous cyst, sclerosing hemanginoma, osteoma, or foreign body granuloma. A high index of suspicion is advantageous in making the clinical diagnosis. An association between pilomatricoma The most common differential diagnosis for this type of lesion is lymphangioma, along with a wide range of other possible diagnoses, such as malignancy, secondary anetoderma, or bullous morphea. For pilomatricomas, surgical incision or curettage is the treatment of choice. Malignant transformation is exceedingly rare The differential diagnosis may be limited further by considering the age of the patient, anatomic location of the lesion, salient imaging features, and clinical manifestations. Introduction Superficial soft-tissue masses are common in clinical practice, and the expanding availability of radiologic imaging has increased radiologists.

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(PDF) Pilomatricoma: another differential in the diagnosis

A pilomatricoma is a rare, benign skin tumour originating from the hair follicle cells. It accounts for 0.15 of skin tumours is. It usually involves the head and neck region. The definitive diagnosis is based on histological examination. The recommended treatment is surgical removal of the lesion Diagnosis of pilomatricoma may be made by clinical findings when the presentation is classic. In the present case, the lesion showed atypical features clinically and it was quite difficult to make preoperative diagnosis. The differential diagnosis of pilomatricoma of head and neck should include sebaceous cyst, ossifying hematoma, brachial. Ultrasonography (US) (both gray-scale and Doppler) is the modality of choice for small, superficial lesions (infantile hemangioma, vascular malformation, pilomatricoma, synovial cyst) or when the clinical history strongly suggests a specific diagnosis (fibromatosis colli, abscess, hematoma, lymphadenitis) (, 1 2) Although rare, a cystic pilomatricoma should be considered in the differential diagnosis of soft tissue masses with calcification. 1. Pirouzmanesh A, Reinisch JF, Gonzalez-Gomez I, Smith EM, Meara JG

Retrospective Study of Pilomatricoma: 261 Tumors in 239

Histopathologically, the major differential diagnosis include both the pigmented and malignant variant of pilomatricoma, matricoma, matrical carcinoma, trichoblastroma and basal cell carcinoma with matrical differentiation. Melanocytic matricoma is both clinically and pathologically distinct from pilomatricoma The evolution can be towards the ulceration and can pose a problem of differential diagnosis with cutaneous carcinoma. Standard radiography is useful only when there is suspicion of a pilomatricoma when it is significantly calcified as is the case in our patient . In all cases, the diagnostic confirmation is histological

Pilomatricoma is difficult to diagnose because of its variant morphology and sometimes unusual appearance that may be similar to more common lesions. Furthermore, because vaccination is a relatively rare cause of pilomatricoma, differential diagnosis could be more difficult in this type of case. Therefore, histopathologic examinations are require Answer of Dermatopathology Case 23. Fine needle aspiration cytology of pilomatrixoma and differential diagnoses.Acta Cytol. 2009 Nov-Dec;53 (6):683-8. OBJECTIVE: To review the cytologic features of pilomatrixoma to allow a definitive diagnosis at the time of aspiration and correct patient management The diagnosis of pilomatricoma is usually suspected clinically and confirmed by histopathological examination. Preoperative imaging is rarely indicated unless its presentation poses a diagnostic dilemma, such as in our case when misdiagnosis of a primary malignant parotid tumor was made followed by multiple inconclusive FNACs Pilomatricoma is a rather uncommon neoplasm in middle-aged and old patients. It is much better known in children. Here, we clinically studied these 4 cases of pilomatricoma in elderly patients (above 50 years of age) to show the variety of clinical differential diagnosis and discuss the clinicopathological features