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Multidrug resistant Klebsiella pneumoniae

Multidrug-resistant (MDR) Klebsiella pneumoniae has become a leading cause of nosocomial infections worldwide. Despite its prominence, little is known about the genetic diversity of K. pneumoniae in resource-poor hospital settings Carbapenemase-resistant Enterobacteriaceae (CRE), in particular carbapenem-resistant Klebsiella pneumoniae (CRKp), represent a serious threat to public health (1). CRKp infections have been associated with high mortality rates, up to 50% in some studies (2) Introduction: Management of antimicrobial resistance in multi-drug-resistant- Klebsiella pneumoniae (MDR-KP) is a major challenge for clinicians. The optimal treatment option for MDR-KP infections is still not well established

New Klebsiella strains 'worst-case scenario,' experts say

Klebsiella pneumoniae is a major pathogen implicated in nosocomial infections. Extended-spectrum β-lactamase (ESBL)-producing K. pneumoniae isolates are a public health concern. We aim to characterize the type of β-lactamases and the associated resistance mechanisms in ESBL-producing K. pneumoniae isolates obtained from blood cultures in a Portuguese hospital, as well as to determine the. Multidrug-resistant Klebsiella pneumoniae . Visualisations. Multidrug-resistant Klebsiella pneumoniae . Antimicrobial resistance. Toggle Dropdown. Percentage of invasive isolates of Klebsiella pneumoniae with combined resistance to fluoroquinolones, third-generation cephalosporins and aminoglycosides (Map Clinical Characteristics of Patients With Positive Culture for Multidrug-Resistant Klebsiella pneumoniae Klebsiella pneumoniae MDR has become a threat to public health; by itself, it has virulence factors related to high mortality as well as low response to treatment Compared to K. pneumoniae, infecting K. variicola isolates were more likely to be from blood (4/5 versus 24/134, p = 0.04), and less likely to be multidrug-resistant (0/5 versus 99/134, p<0.01). No K. variicola isolates demonstrated the hypermucoviscosity phenotype

Drug-resistant Klebsiella Some Klebsiella bacteria have become highly resistant to antibiotics. When bacteria such as Klebsiella pneumoniae produce an enzyme known as a carbapenemase (referred to as KPC-producing organisms), then the class of antibiotics called carbapenems will not work to kill the bacteria and treat the infection Introduction. Klebsiella pneumoniae is recognized as a frequent cause of healthcare-associated infections, including bloodstream infections (BSI), urinary tract infections, ventilator-associated pneumonia, and surgical site infections [].Among military personnel with battlefield injuries sustained in Iraq and Afghanistan, K.pneumoniae was one of the most common colonizing Gram-negative bacilli. Abstract Since the spread of multidrug-resistant Klebsiella pneumoniae (MDRKP) strains is considered as a challenge for patients with weakened or suppressed immunity, the emergence of isolates carrying determinants of hypervirulent phenotypes in addition may become a serious problem even for healthy individuals

Most of K. pneumoniae isolates (n = 21, 84%) were classified as multidrug resistant (MDR) with high-level resistance to β-lactams, aminoglycosides, quinolones, tigecycline, and colistin Klebsiella pneumoniae RH201207 is a multidrug-resistant isolate of clonal group CG258 used in previous transposon insertion sequencing studies (Jana et al. 2017; Short et al. 2020). We first measured K. pneumoniae RH201207 infection parameters in G. mellonella Abstract The emergence of multidrug-resistant Klebsiella pneumoniae is a worldwide problem. K. pneumoniae possesses numerous resistant genes in its genome. We isolated mutants resistant to various.. This report describes a longitudinal case of immunocompromised patient post kidney transplant who was admitted to our institution repeatedly for treatment of various infections caused by multi-drug resistant Klebsiella pneumoniae. The patient was successfully treated with a combination of ertapenem/meropenem on multiple occasions despite the elevated MICs

A high-resolution genomic analysis of multidrug-resistant

  1. The emergence of MDR E. coli and K. pneumoniae is a noticeable problem in different parts of the world and many investigations with various findings has been conducted in recent years (16). In this study, the prevalence of multidrug resistance was 50% among the E. coli isolates and 46.6% among the K. pneumoniae isolates
  2. g organism that can cause pneumocephalus. A woman aged 56 years presented with a history of septic shock and community-acquired pneumonia. She was supported by mechanical ventilation in intensive care unit. Multidrug-resistant K. pneumoniae was detected in her blood and tracheal aspirate
  3. MDR K. pneumoniae ST258 genome sequence. K. pneumoniae ST258 strain RH201207 is a clinical isolate obtained from Public Health England in 2012.RH201207 is resistant to CST, IPM and CIP with.
  4. Molecular Typing and Virulence Analysis of Multidrug Resistant Klebsiella pneumoniae Clinical Isolates Recovered from Egyptian Hospitals Author: Reham Wasfi, Walid F. Elkhatib, and Hossam M. Ashour Created Date: 4/24/2018 10:20:24 P
  5. Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited.
  6. Abstract. Multidrug-resistant and highly virulent Klebsiella pneumoniae isolates are emerging, but the clonal groups (CGs) corresponding to these high-risk strains have remained imprecisely defined. We aimed to identify K. pneumoniae CGs on the basis of genome-wide sequence variation and to provide a simple bioinformatics tool to extract virulence and resistance gene data from genomic data
  7. Klebsiella pneumoniae is a human gut communal organism and notorious opportunistic pathogen. The relative high burden of asymptomatic colonization by K. pneumoniae is often compounded by multidrug resistance—a potential problem for individuals with significant comorbidities or other risk factors for infection. A carbapenem-resistant K. pneumoniae strain classified as multilocus sequence type.

Multidrug-resistant Klebsiella pneumoniae is an increasing cause of infant mortality in developing countries. We aimed to develop a quantitative understanding of the drivers of this epidemic by estimating the effects of antibiotics on nosocomial transmission risk, comparing competing hypotheses about mechanisms of spread, and quantifying the impact of potential interventions Multidrug-resistant (MDR) Klebsiella pneumonia is highly resistant to multiple broad-spectrum antibiotics such as ampicillin and cephalosporins, which were previously helpful in treating these organisms. Hence, its treatment poses a significant challenge to physicians worldwide. The mechanism for its resistance is possibly due to the extended. Tigecycline, a minocycline derivative, remains one of the few therapeutic options for the treatment of infections caused by multidrug-resistant Klebsiella pneumoniae(MDRKP) isolates—including Klebsiella pneumoniaecarbapenemase (KPC) producers—and other Gram-negative organisms (1, 2) Background: The rapid emergence of multidrug-resistant Klebsiella pneumoniae (Kp) is largely driven by the spread of specific clonal groups (CG). Of these, CG147 includes 7-gene MLST sequence types ST147, ST273 and ST392. CG147 has caused nosocomial outbreaks across the world, but its global population dynamics remain unknown. Here, we report a pandrug-resistant ST147 clinical isolate from. A retrospective study on mcr-1 in clinical Escherichia coli and Klebsiella pneumoniae isolates in China from 2007 to 2016. J Antimicrob Chemother. 2018;73(7):1786-1790. 21. Quan J, Li X, Chen Y, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal.

Klebsiella pneumoniae is an important pathogen causing hospital‐acquired infections in human beings. Samples from suspected patients of K pneumoniae associated with respiratory and urinary tract infections were collected at Bolan Medical Complex, Quetta, Balochistan. Clinical samples (n = 107) of urine and sputum were collected and processed for K pneumoniae isolation using selective culture. PURPOSE: Multidrug-resistant Klebsiella pneumoniae strains are regularly involved in hospital outbreaks. This study describes an ESBL-producing K. pneumoniae clone (ST607-K25) responsible for a nosocomial outbreak in a neonatal intensive care unit. METHODOLOGY: Fourteen strains isolated from 13 patients were included

Multidrug-Resistant Klebsiella pneumoniae ST307 in

In this paper we describe the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater and its persistence after chlorine treatment Drug-resistant Klebsiella. Some Klebsiella bacteria have become highly resistant to antibiotics. When bacteria such as Klebsiella pneumoniae produce an enzyme known as a carbapenemase (referred to as KPC-producing organisms), then the class of antibiotics called carbapenems will not work to kill the bacteria and treat the infection. Klebsiella species are examples of Enterobacterales, a normal. In this paper we describe the transmission of a multi-drug resistant Klebsiella pneumoniae ST101 clone from hospital to wastewater and its persistence after chlorine treatment. Water samples from influents and effluents of the sewage tank of an infectious diseases hospital and clinical strains collected from the intra-hospital infections, during a period of 10 days prior to wastewater sampling. KPA (Klebsiella pneumoniae; ATCC 13883) was used as a reference strain. The other clinical strains isolated from nosocomial and community-acquired infections were Klebsiella pneumonia (KP113, KP160, KP229, and KP277). This study on clinical isolates was reviewed and received ethical approval by the Institutional Ethical Committee, Aligarh.

The evolutionary epidemiology, resistome, virulome and mobilome of thirty-one multidrug resistant Klebsiella pneumoniae clinical isolates from the northern Vila Real region of Portugal were. Introduction. Neonatal septicemia, which is mainly hospital-acquired, especially in neonatal intensive care units (NICUs), is becoming more challenging for practitioners to control (1,2).Septicemia and pneumonia are the main symptoms of neonatal sepsis ().Klebsiella pneumoniae (Kp) is a common cause of blood infections. Multidrug-resistant (MDR) strains of Kp, notably extended-spectrum-beta. INTRODUCTION. Klebsiella pneumoniae is a major nosocomial pathogen. Isolates producing extended-spectrum β-lactamase (ESBL) appeared in the early 1980s and were involved in numerous outbreaks, especially in intensive-care units (ICUs) [Reference Cantón 1- Reference Brun-Buisson 3].While hygiene measures permitted the control of ESBL-producing K. pneumoniae nosocomial infections in the. Klebsiella pneumoniae is an opportunistic pathogen associated with both community-acquired and nosocomial infections, including pneumonia, urinary tract infections, septicemia and wound infections, with the increasingly multidrug-resistant (MDR) K. pneumoniae being a major public health concern.. The prevailing hypothesis is that these bacteria acquire multidrug resistance through horizontal.

Phage resistance was evolved in a derivative of the multidrug-resistant K. pneumoniae clinical isolate, KPNIH1, following exposure to natural phages isolated from wastewater. KPNIH1 belongs to the epidemiologically significant sequence type 258 (ST258), which has been associated with high rates of carbapenem resistance and a propensity for. 2 16 Abstract 17 Infections caused by Klebsiella pneumoniae are a major public health threat. Extensively 18 drug-resistant and even pan-resistant strains have been reported. Understanding 19 K. pneumoniae pathogenesis is hampered by the fact that murine models of infection offer 20 limited resolution for the non-hypervirulent strains which cause the majority of infections Introduction. Klebsiella pneumoniae is a notorious nosocomial pathogen responsible for a wide range of healthcare associated infections and is commonly multidrug resistant (MDR). Thus, limited therapeutic options are available to control the infections caused by this pathogen (Martin and Bachman, 2018).However, hypermucoviscous K. pneumoniae, which mostly arises from the community associated. Boonyasiri, A., Jauneikaite, E., Brinkac, L.M. et al. Genomic and clinical characterisation of multidrug-resistant carbapenemase-producing ST231 and ST16 Klebsiella pneumoniae isolates colonising patients at Siriraj hospital, Bangkok, Thailand from 2015 to 2017

However, all K. pneumoniae isolates were sensitive to monobactams and carbapenems. The detection of antibiotic-resistant genes confirmed that the β-lactamase genes ( bla SHV and bla CTX-M ), aminoglycoside modifying enzyme genes [ aac(6′)-Ib , aph(3′)-I and ant(3″)-I ], tetracycline efflux pump ( tetA ) and transposon genetic marker. To investigate the mechanisms of multiple resistance and the horizontal transfer of resistance genes in animal pathogens, we characterized the molecular structures of the resistance gene-related sequences in a multidrug-resistant Klebsiella pneumoniae strain R46 isolated from a rabbit. Molecular cloning was performed to clone the resistance genes, and minimum inhibitory concentrations (MICs.

Multidrug-resistant Klebsiella pneumoniae harboring

Severe infections caused by multidrug-resistant Klebsiella pneumoniae sequence type 258 (ST258) highlight the need for new therapeutics with activity against this pathogen. Bacteriophage (phage) therapy is an alternative treatment approach for multidrug-resistant bacterial infections that has shown efficacy in experimental animal models and promise in clinical case reports. In this study, we. Multidrug-resistant (MDR) Klebsiella pneumoniae is a common infectious pathogen. We performed whole-genome sequencing (WGS) of 39 randomly selected, geographically diverse MDR K. pneumoniae from nine Egyptian hospitals. Clinical sources, phenotypic antibiotic resistance, and hyper-mucoviscosity were documented. WGS data were epidemiologically interpreted and tested for the presence of. The aim of this study is to evaluate the risk factors for colonisation by multidrug resistant (MDR) K. pneumoniae in a critical care unit and the relationship between colonisation and the antibiotic pressure exerted by the antimicrobial treatments received by patients. A prospective observational was designed. Patients admitted for more than 48 h to an intensive care unit were included Background The rapid emergence of multidrug-resistant Klebsiella pneumoniae (Kp) is largely driven by the spread of specific clonal groups (CG). Of these, CG147 includes 7-gene MLST sequence types. Klebsiella pneumoniae: the classical and other subtypes. Klebsiella pneumoniae can be broadly classified into two subtypes; classical Klebsiella pneumoniae (cKp) and non-classical Klebsiella pneumoniae (ncKp). The antimicrobial resistance profiles and the virulence profiles of these strains vary with the former tagged as notorious [3, 5].Notwithstanding, several clones of these ncKp have also.

Reports say highly virulent Klebsiella strains emerged 4

Multidrug-resistant Klebsiella pneumoniae - European

Persisting intrahospital transmission of multidrug-resistant Klebsiella pneumoniae and challenges for infection control. Abstract: In the past several decades, the incidence of Klebsiella pneumoniae harboring resistance mechanisms against multiple antibiotic agents has increased on a global scale Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose-fermenting, facultative anaerobic, rod-shaped bacterium.It appears as a mucoid lactose fermenter on MacConkey agar.. Although found in the normal flora of the mouth, skin, and intestines, it can cause destructive changes to human and animal lungs if aspirated, specifically to the alveoli resulting in bloody, brownish. Klebsiella pneumoniae (K.pneumoniae) from Enterobacteriaceae family is a gram negative bacteria residing in about 40% of human and animals' intestinal tract. It is a type of normal flora localised in mouth, skin and intestine but also an opportunistic human pathogen responsible for 10% of nosocomial infections and 30-50% of exacerbations in hospitalized patients with immunosuppression

A multidrug-resistant Klebsiella pneumoniae outbreak in a

Multidrug-Resistant Klebsiella pneumoniae in Intensive Care Unit Patients: A Nested Case-Control Study Giuseppe Migliara 1,*,†, Valentina Baccolini 1,†, Claudia Isonne 1, Sara Cianfanelli 1, Carolina Di Paolo 1, Annamaria Mele 1, Lorenza Lia 1, Angelo Nardi 1, Carla Salerno 1, Susanna Caminada 1, Vittoria Cammalleri 1 Multidrug-resistant (MDR) Klebsiella pneumoniae represents an increasing threat to human health, causing difficult-to-treat infections with a high mortality rate. Since colistin is one of the few treatment options for carbapenem-resistant K. pneumoniae infections, colistin resistance represents a challenge due to the limited range of potentially available effective antimicrobials, including.

Resistance patterns and clinical outcomes of Klebsiella

Multidrug-resistant Klebsiella pneumoniae from clinical isolates at dr. Soeradji Tirtonegoro central hospital Klaten. Background: Klebsiella pneumoniae is a Gram-negative bacterium that often causes nosocomial infections. Use of broad-spectrum antibiotics as an empiric therapy has contributed to increases of K. Pneumoniae strains that are. Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level. Viacheslav N. Kachalov, Huyen Nguyen, Suraj Balakrishna, Luisa Salazar-Vizcaya, Rami Sommerstein, Stefan P. Kuster, Anthony Hauser, Pia Abel zur Wiesch, Eili Klein, Roger D. Kouyo Klebsiella pneumoniae carbapenemase (KPC) CDC, Management of Multidrug-Resistant Organisms in Healthcare Settings, 2006 (HICPAC), 2006;1-74. SHEA Guidelines for Preventing Nosocomial Transmission of Multidrug-Resistant Strains of Staphylococcus aureus and Enterococcus. Infectio

Klebsiella pneumoniae in Healthcare Settings HAI CD

Carbapenem-resistant Enterobacterales (CRE) Enterobacterales are a large order of different types of germs (bacteria) that commonly cause infections in healthcare settings. Examples of germs in the Enterobacterales order include Escherichia coli ( E. coli) and Klebsiella pneumoniae. Antibiotic resistance occurs when the germs no longer respond. Among the most problematic multidrug-resistant (MDR) bacterial pathogens are the Gram-negative carbapenem-resistant enteric bacteria (CRE), including Klebsiella pneumoniae 1, 2. K. pneumoniae. First multidrug-resistant K. pneumoniae genome from the Northeast region of Brazil.. Genome-based multilocus sequence typing and capsule typing of K. pneumoniae.. Phylogenomic characterization of worldwide Klebsiella spp. strains.. In silico prediction of virulence determinants using genomic information.. Work reinforces the need for genomic surveillance of pathogenic bacteria in Brazil This dataset is an extension of our recent study on the comparative genomics analysis with a multidrug-resistant Klebsiella pneumoniae isolate (B31) from the Northeast of Brazil and other 172. Ultimately, they hope either antibody treatment alone or in combination with antibiotics could greatly improve care for people with multidrug-resistant K. pneumoniae infections. Article. S Kobayashi et al. Antibody-mediated killing of carbapenem-resistant ST258 Klebsiella pneumoniae by human neutrophils. mBio DOI: 10.1128/mBio.00297-18 (2018). Wh

Antibiotic resistance: How has it become a global threat

Multidrug-Resistant Hypervirulent Klebsiella pneumoniae

Antibiotic-resistant Klebsiella pneumoniae is increasingly being implicated in invasive infections worldwide with high mortalities. Forty-two multidrug resistant (MDR) K. pneumoniae isolates were. Multidrug-resistant Klebsiella pneumoniae outbreak after endoscopic retrograde cholangiopancreatography. Endoscopy. 2010; 42 the epidemiologic and molecular investigations of an outbreak of ERCP-related severe nosocomial infection due to KLEBSIELLA PNEUMONIAE producing extended-spectrum beta-lactamase (ESBL)

Infections With &#39;Nightmare Bacteria&#39; Are On The Rise In U

High Prevalence of Multidrug-Resistant Klebsiella

Multidrug-resistant CTX-M-15-producing Klebsiella pneumoniae ST231 associated with infection and persistent colonization of dog Author links open overlay panel Meire M. Silva a Miriam R. Fernandes b Fábio P. Sellera c Louise Cerdeira b Lylian K.G. Medeiros a Felício Garino a Sérgio S. Azevedo a Nilton Lincopan Bacteria producing Klebsiella pneumoniae carbapenemases (KPCs) are rapidly emerging as a cause of multidrug-resistant infections worldwide. Bacterial isolates harbouring these enzymes are capable of hydrolysing a broad spectrum of β-lactams including the penicillins, cephalosporins, carbapenems and monobactam 1. Introduction. Klebsiella pneumoniae is one of the most important Gram-negative nosocomial pathogens. With the wide application of antibacterial drugs, multidrug-resistant (MDR) and extensively drug-resistant K. pneumoniae have emerged, posing a great challenge for the antibacterial treatment of clinical infections .Among several resistance mechanisms, overexpression of efflux pumps is an. In this study, we isolated lytic phages capable of infecting a modified Klebsiella pneumoniae clinical isolate and characterized a total of 57 phage-resistant mutants that evolved from their prolonged coculture in vitro. Single- and double-phage-resistant mutants were isolated from independently evolved replicate cocultures grown in broth or on.

Infections caused by multidrug-resistant (MDR), carbapenemase-producing (CP) Klebsiella pneumoniae (Kp) are responsible for a rapidly growing burden of disease worldwide [].Among hospitalized adults, asymptomatic carriage of MDR Enterobacterales (ie, colonization) precedes, and significantly augments, the risk of developing infections caused by these microorganisms [] Abstract. The objective of this study is to identify the risk factors related to colonization or infection in an outbreak of multidrug-resistant Klebsiella pneumoniae in a burn patient unit. The authors studied the risk factors associated with colonization or infection using a case-control study design involving patients with multidrug resistant K. pneumoniae (n = 26) and controls (n = 50) The extended-spectrum-β-lactamase (ESBL)- and Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae represent serious and urgent threats to public health. In a retrospective study of multidrug-resistant K. pneumoniae, we identified three clinical isolates, CN1, CR14, and NY9, carrying both blaCTX-M and blaKPC genes Community-acquired pneumonia (CAP) is associated with high morbidity and mortality worldwide [].Although several different bacteria and respiratory viruses can be responsible for CAP, Streptococcus pneumoniae (pneumococcus) remains the most common causative pathogen. A small proportion of CAP cases are caused by Gram-negative bacteria, especially Pseudomonas aeruginosa, Klebsiella pneumoniae. An isolate is said to be multidrug resistant if it is resistant to three or more antimicrobial classes. We found that 95% of the isolates were multidrug resistant species. Multidrug resistance in Klebsiella species varies in different parts of the world. In India, 54% was reported [22] and in Nigeria 75.8% [23]

Identifying virulence determinants of multidrug-resistant

microorganisms Article Isolation and Characterization of a Novel Phage for Controlling Multidrug-Resistant Klebsiella pneumoniae Qin Peng 1, Meng Fang 1, Xushan Liu 1, Chunling Zhang 1, Yue Liu 1 and Yihui Yuan 2,* 1 Ministry of Education Key Laboratory for Ecology of Tropical Islands, College of Life Sciences, Hainan Normal University, Haikou 571158, China; pengqin1019@hainnu.edu.cn (Q.P.) Multidrug-resistant and highly virulent Klebsiella pneumoniae isolates are emerging, but the clonal groups (CGs) corresponding to these high-risk strains have remained imprecisely defined. We aimed to identify K. pneumoniae CGs on the basis of genome-wide sequence variation and to provide a simple bioinformatics tool to extract virulence and. Klebsiella pneumonia (KP) has emerged as an increasingly important cause of community-acquired nosocomial infections and many of these strains are highly virulent with multidrug resistance (MDR.

The role of RND-type efflux pumps in multidrug-resistant

Original Report Epidemiology and Molecular Characterization of Nosocomially Transmitted Multidrug-Resistant Klebsiella pneumoniae Navaratnam Parasakthi, MRCPath;* Jamuna Vadivelu, PhD;* Hany Ariffin, MPaed, MRCP;+ Lakshmy Iyer, MSc,** Selvi Palasubramaniam, MSc; * and Anusha Arasu, MRCPt ABSTRACT Key Words: extended-spectrum beta-lactamase, molecular epidemiology multiresistant Klebsiella. MDR-PA, multidrug-resistant Pseudomonas aeruginosa; CR-KP, carbapenem-resistant Klebsiella pneumoniae. a Isolate unavailable for molecular analysis. b Possible outbreak: patients whose death occurred within 10 days of bronchoscope B1 exposure such that subsequent recovery and epidemiologic classification of isolates from clinical cultures could. The results showed that ESBL/AmpC-producing Klebsiella pneumoniae (ESBL/AmpC-KP) isolated from horses have co-resistance to other β-lactam antibiotics as multidrug-resistant (MDR) bacteria. Genetic relatedness analysis suggested that plasmid-mediated AmpC-KP clones may spread between horses

Shen, D. et al. Emergence of a multidrug-resistant hypervirulent Klebsiella pneumoniae sequence type 23 strain with a rare bla CTX-M-24-harboring virulence plasmid. Antimicrob Agents Chemother. 63. In the past several decades, the incidence of Klebsiella pneumoniae harboring resistance mechanisms against multiple antibiotic agents has increased on a global scale. We discuss reasons for ongoing transmission of multidrug-resistant K. pneumoniae in healthcare settings, which has resulted in the successful spread and establishment of this. Abstract. Permatasari DA, Witaningrum AM, Wibisono FJ, Effendi MH. 2020. Detection and prevalence of multidrug-resistant Klebsiella pneumoniae strain isolated from poultry farms in Blitar, Indonesia. Biodiversitas 21: 4642-4647. Antibiotics are commonly used as therapy and disease control in humans and animals. However, the widespread use of antibiotics may also trigger the rise of antibiotic. The emergence of multidrug-resistant bacterial pathogens has severely threatened global health. A phage with the ability to efficiently and specifically lyse bacteria is considered an alternative for controlling multidrug-resistant bacterial pathogens. The discovery of novel agents for controlling the infections caused by K. pneumoniae is urgent due to the broad multidrug-resistance of K. Introduction. Klebsiella pneumoniae is an important facultative pathogen that causes hospital and community infections. 1 According to data provided by the Chinese antimicrobial resistance surveillance system (CARSS), K. pneumoniae is the second most prevalent (20.2%) among the isolated gram-negative pathogens. 2 An increasing number of studies have shown that K. pneumoniae also causes a.

Comparative Clinical Study Between Colistin-Tigecycline Combined Therapy Versus Colistin-Meropenem Combined Therapy in Treatment of Blood Stream Infections With Multidrug-Resistant Klebsiella Pneumoniae: Actual Study Start Date : September 21, 2019: Estimated Primary Completion Date : July 2020: Estimated Study Completion Date : July 202 Abstract. CTX-M extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae isolates are infrequently reported in the United States. In this study, we analyzed nonduplicate ESBL-producing K. pneumoniae and Escherichia coli clinical isolates collected during 2005-2012 at a tertiary care medical center in suburban New York City, USA, for the presence of bla CTX-M, bla SHV, bla TEM. ORIGINAL ARTICLE BACTERIOLOGY Bloodstream infections among carriers of carbapenem-resistant Klebsiella pneumoniae: etiology, incidence and predictors S. Amit1, H. Mishali2, T. Kotlovsky2, M. J. Schwaber2 and Y. Carmeli2,3 1) Infectious Disease Unit, 2) The National Centre for Antibiotic Resistance and Infection Control, and 3) Division of Epidemiology, Tel Aviv Medical Centre, Tel-Aviv, Israel. Klebsiella pneumoniae is a common cause of nosocomial infections. Antibiotic resistance and ability to form biofilm, as two key virulence factors of K. pneumoniae, are involved in the persistence of infections. The purpose of this study was to investigate the correlation between antimicrobial resistance and biofilm formation capability among K. pneumoniae strains isolated from hospitalized. Methods and Results. The effect of seven EOs and three enzymes was tested on formation and eradication of K. pneumoniae biofilm. Peppermint oil showed a robust biofilm inhibitory effect, causing inhibition that ranged from 69·2 to 98·2% at 5 μl ml −1.Thyme oil was found to have the best biofilm eradication ability, causing eradication that ranged from 80·1 to 98·0% at 10 μl ml −1

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